This is a very interesting study in which 500 board certified internists were presented with abstracts that described a clinical trial of three hypothetical drugs. The trials had a high, a medium or a low level of quality and each report had included a disclosure about the source of funding, either from a pharmaceutical company, […]
An interesting and exciting study has recently been published in The Lancet by Warnecke et al describing the use of a portable perfusion unit for lung preservation. The “OCS Lung” (TransMedics, Andover MA) is a mobile and stand-alone unit that can be used to perfuse donor lungs from the start of the preservation period, minimizing cold iscaemic […]
The October edition of the Transplant Trial Watch is now available on the CET website. Each month, our team summarise and assess the quality of 10 important randomised controlled trials in the field of solid organ transplantation. This month, trials include sirolimus in the prevention of skin cancer in transplant recipients, machine perfusion in extended […]
This is quite a fascinating study and is a phase 2 randomised double blind study of cellular treatment of venous ulcers. Patients with non healing venous ulcers of the lower leg were treated with either the vehicle (fibrinogen and thrombin) – control group or with 4 different protocols of the vehicle with fibroblast and keratinocyte […]
The September edition of the Transplant Trial Watch is now available on the CET website. Each month, the CET staff select 10 recently published randomised controlled trials in the field of transplantation and summarise the findings and quality. This month, the Trial Watch includes a trial of generic tacrolimus, long-term results from the Tricontinental MMF […]
Sylvie Euvrard and her colleagues (New England Journal of Medicine 2012; 367:329) have performed a multicentre randomised trial in patients on a calcineurin inhibitor who had developed at least 1 squamous cell cancer of the skin after renal transplantation. Patients were randomised to either continue on the calcineurin inhibitor or to be converted to sirolimus. […]
The July edition of the Transplant Trial Watch is now available on our website. Each month, the CET staff select and assess the quality of 10 important randomised controlled trials in the transplant literature. This month, trials include improving dontation rates, treating recurrent HCV after liver transplantation, and CNI vs MMF withdrawal in renal transplantation. […]
There was a very interesting report in the Lancet this past week from the Sahlgrenska University Hospital in Gothenburg in Sweden by Michael Olausson and colleagues describing the successful treatment of a ten year old girl with an extrahepatic portal vein obstruction. A 9cm length of an iliac vein from a deceased organ donor was […]
The June edition of the Transplant Trial Watch is now available on our website. Each month, the CET staff select and assess the quality of 10 important randomised controlled trials in the transplant literature. Don’t forget that the Trial Watch is now available as an app for Android and iPhone – Download it now!