The Collaborative Transplant Study ( CTS ) first newsletter for 2014 (February 1 – available to CTS participants only) presents a particularly important analysis of outcomes of deceased donor kidneys between 2003 and 2012 based on the tacrolimus trough levels one year after transplantation. If the maintenance trough levels were less than 5ng/mL there was a significantly worse graft […]
The World Kidney Day for 2014 is to be March 13th and it is featuring chronic kidney disease and ageing. They make the point that although chronic kidney disease can occur at any age it becomes more common with increasing age, and indeed after the age of 40 kidney filtration begins to fall by approximately 1% […]
The March 2014 edition of the Transplant Trial Watch is now available online and via the CET’s app for iPhone, iPad and Android. This month, trials include the effects of cyclosporin A and tacrolimus on fibrosis following liver transplantation for hepatitis C, intravesical vs. extravesical ureteroneocystostomy in renal transplantation and the use of sitagliptin in […]
My co-editor (Stuart Knechtle) and I are delighted to announce that the 7th edition of this textbook has appeared. This edition is accompanied by access to an electronic edition which is a first for this book and has all relevant illustrations in colour together with a number of video clips. I published the first edition in 1978 […]
The January 2014 edition of the Transplant Trial Watch is now available. This month’s new trials include Letermovir for post-transplant CMV infection, a suggestion that Alemtuzumab increases de-novo DSA production and a phase I study of a novel TLR-2 monoclonal antibody. You can read the CET’s summaries of these trials (and more) on the CET […]
The December 2013 edition of the transplant trial watch is now available on the CET site, as well as via our app for iPhone, iPad and Android. This month trials include long-term follow-up of the BENEFIT study, hand assisted retroperitoneoscopic nephrectomy and steroid-free renal transplantation with Alemtuzumab induction.
A group from Sun Yat-sen University, Guangzhou, China has recently published a systematic review comparing the outcomes in patients receiving kidneys from donation after cardiac death (DCD). Deng et al conducted a meta-analysis using the results from four randomised controlled trials (351 kidneys). Machine perfusion reduced the rate of delayed graft function compared to static […]
Researchers in Boston, Massachusetts have published the first description of successful transplantation of a bioengineered kidney into rats. The paper, published in this week’s Nature Medicine describes the process of decellularization by detergent perfusion and regeneration with epithelial and endothelial cells. The resulting kidney was capable of filtering and producing urine both in vitro and […]
A cluster of cases of pneumocystis pneumonia has been reported from the Westmead hospital transplant unit in Sydney. All patients had had conventional prophylaxis, namely treatment with trimethoprin/sulfamethoxazole for 6 months after transplantation. These cases have all been documented very carefully and the pneumocystis jiroveci have been genotyped and the authors produce convincing evidence that this […]
The October edition of the Transplant Trial Watch is now available on the CET website. Each month, our team summarise and assess the quality of 10 important randomised controlled trials in the field of solid organ transplantation. This month, trials include sirolimus in the prevention of skin cancer in transplant recipients, machine perfusion in extended […]