Intention to treat analysis
At the Centre for Evidence in Transplantation (CET) we have been rating the methodological quality of randomised controlled trials (RCTs) published since 2004. The quality score is a composite score assessing allocation concealment, intention to treat (ITT) analysis and the Jadad scale which comprises items on the adequate description of randomisation, double blinding and withdrawals. […]
Are clinical trials relevant?
Last month, an interesting article in Transplantation by Blosser et al. (Transplantation 91(8):858) explored the issue of generalisability of clinical trials to patients outside of the clinical trial setting. The authors identified 573 randomised clinical trials (RCTs) in kidney transplant recipients in the period between 1999 and 2008, and found that 30% had an exclusion […]