To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
April 2025
Kidney transplantation
Prophylaxis for renal patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial.
Humphrey, T. J. L., et al. BMC Infectious Diseases 2025; 25(1): 204.
Induction of Immune Tolerance in Living Related HLA-Matched Kidney Transplantation: A Phase 3 Randomized Clinical Trial.
Kaufman, D. B., et al American Journal of Transplantation 2025 [record in progress].
Long-term Double-J stenting is superior to short-term Single-J stenting in kidney transplantation.
Oudmaijer, C. A. J., et al. PLoS ONE [Electronic Resource] 2025; 20(1): e0317991.
Safety and efficacy of direct oral anticoagulants in kidney transplant recipients: A systematic review and meta-analysis.
Roca Mora, M. M., et al. Transplantation Reviews 2025; 39(1): 100899.
Cytomegalovirus Antiviral Resistance Among Kidney Transplant Recipients in a Phase 3 Trial of Letermovir vs Valganciclovir Prophylaxis.
Strizki, J. M., et al. Journal of Infectious Diseases 2024; 230(6): e1287-e1298.
Liver transplantation
Fully covered self-expandable metal stents versus multiple plastic stents for the treatment of post-orthotopic liver transplant anastomotic biliary strictures: An updated systematic review and meta-analysis of randomized controlled trials.
Baraldo, S., et al. Surgical Endoscopy 2025; 39(2): 721-729.
Impact of pre-transplant immune checkpoint inhibitor use on post-transplant outcomes in HCC: A systematic review and individual patient data meta-analysis.
Rezaee-Zavareh, M. S., et al. Journal of Hepatology 2025; 82(1): 107-119.
Real-Time Biomarkers of Liver Graft Quality in Hypothermic Oxygenated Machine Perfusion.
Zhylko, A., et al. Journal of clinical medicine 2025; 14(2): 13.
Various organs
Nurse-Led Self-Management Support After Organ Transplantation - A Multicenter, Stepped-Wedge Randomized Controlled Trial.
van Zanten, R., et al. Transplant International 2024; 37: 13175.
Other
The impact of pancreas transplantation on diabetic complications: A systematic review.
Giri, G., et al. Transplantation Reviews 2025; 39(2): 100910.