A Comparative Study of Impact of Infusion of Ringer's Lactate Solution versus Normal Saline on Acid-base Balance and Serum Electrolytes during Live Related Renal Transplantation.
Modi MP, Vora KS, et al.Saudi Journal of Kidney Diseases & Transplantation, 23(1): 135-137, 2012.
Aims
To evaluate the impact of infusion of Ringer’s lactate solution on acid-based balance and serum electrolytes during live related renal transplantation.
Interventions
Infusion of Ringer’s lactate solution versus normal saline during live related renal transplantation. All patients were given methylprednisolone 500 mg intra-operatively after induction of anesthesia. Manitol and frusemide were administered to all patients before release of vascular clamps.
Participants
74 patients with chronic renal failure undergoing live related renal transplantation.
Outcomes
Serum electrolytes including bicarbonate, potassium, chloride concentrations and PH value; total urine output during operation, total urine volume and serum creatinine on the 1st day post-transplantation.
Follow-up
1 day post-transplantation
CET Conclusions
In this good quality double blinded study the authors show that Ringers lactate solution used for infusion during the perioperative renal transplant period compared to normal saline is safe, and does not result in any rise in potassium. Indeed Ringer’s Lactate solution may be superior to normal saline because it avoids the risk of metabolic acidosis and clinical hyperkalemia.
Data analysis
Per protocol analysis
Trial registration
Not reported