Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation.
Zhu X, Wu Y, et al.World Journal of Gastroenterology 2012; 18(42):6141-6147.
Aims
To investigate the liver-protecting effect of parenteral nutrition (PN) support with omega-3 fatty acids.
Interventions
PN without supplementation of omega-3 fatty acids in addition to routine treatment versus PN supplemented with omega-3 fatty acids in addition to routine treatment.
Participants
66 patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma.
Outcomes
Clinical outcomes included posttransplant mechanical ventilation, total hospital stay, infectious morbidities (pneumonia, intra-abdominal abscess, central line sepsis, wound infection, and urinary tract infection), acute and chronic rejection, mortality intensive care unit mortality, hospital mortality, 28-day mortality, and survival at one year post-transplant), liver function assessment (serum total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase lactate dehydrogenase and prothrombin time).
Follow-up
12 months
CET Conclusions
After liver transplantation parenteral nutrition supplemented with omega-3 fatty acids for 7 days does seem to improve liver function and perhaps reduces subsequent infections and the post transplant hospital stay compared to standard parenteral nutrition.
Data analysis
Per protocol analysis
Trial registration
Not reported