The effect of octreotide on urine output during orthotopic liver transplantation and early postoperative renal function; a randomized, double-blind, placebo-controlled trial.
Sahmeddini M A, Amini A, et al.Hepatitis Monthly 2013; 13(9): e12787.
Aims
To evaluate the effect of octreotide and norephrine on urine output and early postoperative renal function in patients undergoing orthotopic liver transplantation (OLT).
Interventions
Patients received either norephrine alone or a combination of norephrine and octreotide.
Participants
79 end-stage liver disease candidates for orthotopic deceased donor liver transplantation.
Outcomes
The primary outcome of the study was the urine output measurement during the three stages of the operation. The secondary outcome was the serum creatinine levels on the first and third days post operation.
Follow-up
Not reported
CET Conclusions
This study demonstrated an increase in recipient urine output during all phases of liver transplantation when octreotide was used to supplement noradrenaline compared to noradrenaline alone. The increased urine output was matched also by a significant increase in mean arterial pressure during these phases as well. Importantly the higher urine output did not translate to a decrease in serum creatinine during the three first days after transplantation. One does have to wonder what the outcomes would have been like had the study had a longer follow up than this. Unfortunately the short follow up and small study size also makes it very difficult to evaluate the safety of the proposed intervention.
Data analysis
Modified intention-to-treat analysis
Trial registration
IRCT2012120411662N1