Calcineurin Inhibitors Acutely Improve Insulin Sensitivity without Affecting Insulin Secretion in Healthy Human Volunteers.
Ozbay LA, Moller N, et al.British Journal of Clinical Pharmacology, 73(4); 536-545, 2012
Aims
This randomized, double-blind, cross-over study sought to compare the impact of cyclosporine (CsA) and tacrolimus (Tac) on glucose metabolism in healthy human subjects.
Interventions
5-hour infusions of CsA versus Tac versus saline.
Participants
Ten healthy men.
Outcomes
Clamp derived insulin sensitivity, first phase and pulsatile insulin secretion. high sensitive c-reactive protein levels, circulating glucagon, serum free fatty acids and adiponectin levels.
Follow-up
5 hours
CET Conclusions
Both drugs acutely increased insulin sensitivity while first phase pulsatile insulin secretion remained unchanged. Thus this would suggest that cyclosporine and tacrolimus have similar acute effects on glucose metabolism in healthy humans.
Data analysis
Per protocol analysis
Trial registration
NCT00766909 (Clinicaltrials.gov)