To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
November 2011
Kidney transplantation
The PROMISE Study: A Phase 2b Multicenter Study of Voclosporin (ISA247) Versus Tacrolimus in De Novo Kidney Transplantation.
Busque S. Cantarovich M et al. American Journal of Transplantation, 11(12): 2675-2684, 2011.
Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy-an open label, randomized trial.
Chan K. Taube D et al. Transplantation. 92(7): 774-80, 2011
Steroid or tacrolimus withdrawal in renal transplant recipients using sirolimus.
de Sandes Freitas TV, Harada KM et al. International urology and nephrology. 43(4): 1221-1228, 2011.
A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients.
Elens L. Bouamar R. et al. Clinical Chemistry. 57(11): 1574-1583, 2011.
FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.
Hoitsma AJ. Woodle ES. et al. Nephrology Dialysis Transplantation. 26(11): 3802-5, 2011.
Immunosuppressant Regimen Based on Sirolimus Decreases Aortic Stiffness in Renal Transplant Recipients in Comparison to Cyclosporine.
Joannides R. Monteil C et al. American Journal of Transplantation. 11(11): 2414-22, 2011.
Liver transplantation
Impact of stable PGI(2) analog iloprost on early graft viability after liver transplantation: a pilot study.
Barthel E. Rauchfuss F et al. Clinical Transplantation, 26: E38–E47, 2012.
Use of stepwise versus straightforward clamping of biliary drainage tubes after living-donor liver transplantation: a prospective, randomized trial.
Eguchi S. Takatsuki M et al. Journal of Hepato-biliary-pancreatic Sciences. 19(4) 379-381, 2011
Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation.
Yoshida R. Yagi T et al. Journal of hepato-biliary-pancreatic sciences. 19(4) 438-448, 2011.
Combination adjuvant chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin after liver transplantation for hepatocellular carcinoma: a preliminary open-label study.
Zhang Q. Chen H et al. Investigational New Drugs. 29(6): 1360-9, 2011