To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
January 2012
Kidney transplantation
Donor Desmopressin Is Associated With Superior Graft Survival After Kidney Transplantation.
Benck U, Gottmann U, et al. Transplantation 92(11): 1252-1258, 2011.
Effects of anti-adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts.
Cheadle C, Watkins T, et al. Clinical Transplantation 25(5): 766-775, 2011.
The Primavera study protocol design: evaluating the effect of continuous erythropoiesis receptor activator (C.E.R.A.) on renal function in non-anemic patients with chronic kidney disease.
Fliser D, Dellanna F, et al. Contemporary Clinical Trials 32(6): 786-792, 2011.
Impact of Early Conversion From Tacrolimus to Sirolimus on Chronic Allograft Changes in Kidney Recipients on Rapid Steroid Withdrawal.
Heilman R, Cortese LC, et al. Transplantation 93 (1):47-53, 2012
Early Steroid Withdrawal and Optimization of Mycophenolic Acid Exposure in Kidney Transplant Recipients Receiving Mycophenolate Mofetil.
Le Meur Y, Thierry A, et al. Transplantation 92(11):1244-51, 2011
De novo use of everolimus with elimination or minimization of cyclosporine in renal transplant recipients.
Novoa, PA, Grinyo JM, et al. Transplantation Proceedings 43(9): 3331-3339, 2011.
Valganciclovir Prophylaxis Versus Preemptive Therapy in Cytomegalovirus-Positive Renal Allograft Recipients: 1-Year Results of a Randomized Clinical Trial.
Witzke O, Hauser I A, et al. Transplantation 93(1):61-8, 2012.
Liver transplantation
Attempt to rescue discarded human liver grafts by end ischemic hypothermic oxygenated machine perfusion.
Vekemans K, van Pelt J, et al. Transplantation Proceedings 43(9): 3455-3459, 2011.
Heart transplantation
Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trial.
Benck U, Hoeger S, et al. Journal of the American College of Cardiology 58(17): 1768-1777, 2011
Creation of a quantitative recipient risk index for mortality prediction after cardiac transplantation (IMPACT).
Weiss E, Allen J, et al. Annals of Thoracic Surgery 92(3): 914-921, 2011; discussion 921-912.