To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
April 2012
Kidney transplantation
A 39-Month Follow-up Study to Evaluate the Safety and Efficacy in Kidney Transplant Recipients Treated With Modified-Release Tacrolimus (FK506E)-Based Immunosuppression Regimen.
Han DJ, Park JB, et al. Transplantation Proceedings, 44(1): 115-117, 2012.
Donor-Specific HLA Antibodies in a Cohort Comparing Everolimus with Cyclosporine After Kidney Transplantation
Liefeldt L, Brakemeier S, et al. American Journal of Transplantation, 12(5):1192-8, 2012.
A Randomized Controlled Trial of Intravenous or Oral Iron for Posttransplant Anemia in Kidney Transplantation.
Mudge DW, Tan KS, et al. Transplantation, 93(8): 822-826, 2012.
Effect of Everolimus on Left Ventricular Hypertrophy of de novo Kidney Transplant Recipients: a 1 Year, Randomized, Controlled Trial.
Paoletti E, Marsano L, et al. Transplantation, 93(5): 503-508, 2012.
Three-Year Outcomes From BENEFIT-EXT: A Phase III Study of Belatacept Versus Cyclosporine in Recipients of Extended Criteria Donor Kidneys.
Pestana JO, Grinyo JM, et al. American Journal of Transplantation, 12(3): 630-639, 2012.
Single-dose rATG Induction at Renal Transplantation: Superior Renal Function and Glucoregulation with Less Hypomagnesemia
Stevens RB, Lane JT, et al. Clinical Transplantation, 26(1): 123-132, 2012.
Liver transplantation
The Effect of Steroid Pretreatment of Deceased Organ Donors on Liver Allograft Function: A Blinded Randomized Placebo Controlled Trial.
Amatschek S, Wilflingseder J, et al. Journal of Hepatology, 56(6):1305-9, 2012.
Daily Ciprofloxacin Treatment for Patients with Advanced Liver Disease Awaiting Liver Transplantation Reduces Hospitalizations.
Minuk GY, Hawkins K, et al. Digestive Diseases & Sciences, 56(4): 1235-41, 2011.
Heart transplantation
Cyclosporine Lowering with Everolimus versus Mycophenolate Mofetil in Heart Transplant Recipients: Long-term Follow-up of the SHIRAKISS Randomized, Prospective Study.
Potena L, Prestinenzi P, et al. Journal of Heart & Lung Transplantation, 31(6):565-70, 2012.
Various organs
Improvement in Renal Function after Everolimus Introduction and Calcineurin Inhibitor Reduction in Maintenance Thoracic Transplant Recipients: The Significance of Baseline Glomerular Fltration Rate.
Arora S, Gude E, et al. Journal of Heart & Lung Transplantation, 31(3): 259-265, 2012.