To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
August 2012
Kidney transplantation
Conversion from Cyclosporine to Everolimus at 4.5 Months Posttransplant: 3-Year Results From the Randomized ZEUS Study.
Budde K, Lehner F, et al. American Journal of Transplantation, 12(6): 1528-1540, 2012.
Inflammation-associated Graft Loss in Renal Transplant Recipients.
Dahle D, Mjoen G, et al. Nephrology Dialysis Transplantation, 26(11): 3756-3761, 2011.
Efficacy and Safety of Early Cyclosporine Conversion to Sirolimus with Continued MMF—Four-Year Results of the Postconcept Study.
Lebranchu Y, Thierry A, et al. American Journal of Transplantation, 11(8): 1665-1675, 2011.
Lipid Peroxidation Products in Machine Perfusion of Older Donor Kidneys.
Nagelschmidt M, Minor T, et al. Journal of Surgical Research, [record in progress].
A Cardiovascular Risk Calculator for Renal Transplant Recipients.
Soveri I, Holme I, et al. Transplantation, 94(1):57-62, 2012.
Steroid Avoidance with Early Intensified Dosing of Enteric-coated Mycophenolate Sodium: A Randomized Multicentre Trial in Kidney Transplant Recipients.
Thierry A, Mourad G, et al. Nephrology Dialysis Transplantation, 27(9):3651-3659, 2012.
Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year.
Vincenti F, Tedesco Silva H, et al. American Journal of Transplantation, 12(9): 2446-2456, 2012.
Liver transplantation
Twenty-four Hour Steroid Avoidance Immunosuppressive Regimen in Liver Transplant Recipients.
Ju WQ, Guo ZY, et al. Experimental & Clinical Transplantation, 10(3): 258-262, 2012.
Oral Valganciclovir versus Intravenous Ganciclovir as Preemptive Treatment for Cytomegalovirus Infection after Living Donor Liver Transplantation: A randomized Trial.
Togashi J, Sugawara Y, et al. Bioscience Trends, 5(5): 217-222, 2011.
Heart transplantation
Effects of Exercise Training on Exercise Capacity and Quality of Life in Patients with a Left Ventricular Assist Device: A Preliminary Randomized Controlled Trial.
Hayes K, Leet AS, et al. Journal of Heart & Lung Transplantation, 31(7): 729-734, 2012.