To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
December 2012
Kidney transplantation
A randomized clinical trial of living donor nephrectomy: a plea for a differentiated appraisal of mini-open muscle splitting incision and hand-assisted laparoscopic donor nephrectomy.
Hofker HS, Nijboer WN, et al. Transplant International 2012; 25(9):976-86.
Randomized Clinical Trial of Transversus Abdominis Plane Block Versus Placebo Control in Live-Donor Nephrectomy.
Hosgood SA, Thiyagarajan UM, et al. Transplantation 2012; 94(5):520-5.
Randomized, single blind, controlled trial to evaluate the prime-boost strategy for pneumococcal vaccination in renal transplant recipients.
Tobudic S, Plunger V, et al. PLoS ONE [Electronic Resource] 2012; 7(9): e46133.
Liver transplantation
Plasma transfusion in liver transplantation: a randomized, double-blind, multicenter clinical comparison of three virally secured plasmas.
Bartelmaos T, Chabanel A, et al. Transfusion [record in progress].
A comparison of intra-operative blood loss and acid-base balance between vasopressor and inotrope strategy during living donor liver transplantation: a randomised, controlled study.
Hong SH, Park CS, et al. Anaesthesia 2012; 67(10): 1091-1100.
Heart transplantation
Everolimus is associated with a reduced incidence of cytomegalovirus infection following de novo cardiac transplantation.
Kobashigawa J, Ross H, et al. Transplant Infectious Disease [record in progress].
Lung transplantation
Interval versus continuous training in lung transplant candidates: A randomized trial.
Gloeckl R, Halle M, et al. The Journal of Heart and Lung Transplantation 2012; 31(9): 934-941.
Comparison of lung preservation solutions in human lungs using an ex vivo lung perfusion experimental model.
Medeiros IL, Pego-Fernandes PM, et al. Clinics 2012; 67(9): 1101-1106.
Various organs
Advantage of Rapamycin Over Mycophenolate Mofetil When Used with Tacrolimus for Simultaneous Pancreas Kidney Transplants: Randomized, Single-Center Trial at 10 Years.
Ciancio G, Sageshima J, et al. American Journal of Transplantation [record in progress]
Other
The evaluation of potential pharmacokinetic interaction between sirolimus and tacrolimus in healthy volunteers.
Tortorici MA, Parks V, et al. European Journal of Clinical Pharmacology [record in progress]