To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
April 2013
Kidney transplantation
Long-term outcomes after cyclosporine or mycophenolate withdrawal in kidney transplantation - results from an aborted trial.
Asberg A, Apeland T, et al. Clinical Transplantation. 2013; 27(2): 151-156
Effects of tight versus non tight control of metabolic acidosis on early renal function after kidney transplantation.
Etezadi F, Pourfakhr P, et al. Daru 2012; 20(1): 36
Two-year randomized controlled prospective trial converting treatment of stable renal transplant recipients with cutaneous invasive squamous cell carcinomas to sirolimus.
Hoogendijk-van den Akker JM, Harden PN, et al. Journal of Clinical Oncology. 2013; 31(10): 1317-1323
Effects of ACE inhibitors on long-term outcome of renal transplant recipients: a randomized controlled trial.
Paoletti E, Bellino D, et al. Transplantation. 2013; 95(6):889-95.
Rationale and design of the RIACT--study: a multi-center placebo controlled double blind study to test the efficacy of rituximab in acute cellular tubulointerstitial rejection with B-cell infiltrates in renal transplant patients: study protocol for a randomized controlled trial.
Schiffer L, Schiffer M, et al. Trials 2012; 13(1): 199.
Vildagliptin and pioglitazone in patients with impaired glucose tolerance after kidney transplantation: a randomized, placebo-controlled clinical trial.
Werzowa J, Hecking M, et al. Transplantation 2013; 95(3): 456-462.
Liver transplantation
The PRAISE study: A prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of iloprost in the early postoperative period after liver transplantation.
Barthel, E, Rauchfuss F, et al. BMC Surgery 2013; 13(1): 1.
Human Monoclonal Antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study.
Chung R T, Gordon F D, et al. American Journal of Transplantation. 2013; 13(4):1047-54
Effect of active airway warming on body core temperature during adult liver transplantation.
Han SB, Gwak MS, et al. Transplantation Proceedings 2013; 45(1): 251-254
Comparison of harmonic scalpel versus conventional knot tying for transection of short hepatic veins at liver transplantation: prospective randomized study.
Olmez A, K Karabulut, et al. Transplantation Proceedings 2012; 44(6): 1717-1719.