To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
May 2013
Kidney transplantation
Randomized trial of everolimus-facilitated calcineurin inhibitor minimization over 24 Months in renal transplantation.
Cibrik D, Silva HT Jr, et al. Transplantation. 2013; 95(7):933-42
Acute rejection characteristics from a prospective, randomized, double-blind, placebo-controlled multicenter trial of early corticosteroid withdrawal.
Gaber AO, Moore LW, et al. Transplantation 2013; 95(4): 573-579.
Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation.
Suszynski TM, Gillingham KJ, et al. American Journal of Transplantation. 2013; 13(4):961-970.
Randomized comparative trial of mizoribine versus mycophenolate mofetil in combination with tacrolimus for living donor renal transplantation.
Takahara S, Takahashi K, et al. Clinical and Experimental Nephrology [record in progress].
Liver transplantation
T-tube or no T-tube in cadaveric orthotopic liver transplantation: the eternal dilemma: results of a prospective and randomized clinical trial.
Lopez-Andujar R, Montalva Oron E, et al. Annals of Surgery 2013; 258(1):21-9.
A prospective, randomized trial of complete avoidance of steroids in liver transplantation with follow-up of over 7 years.
Pelletier SJ, Nadig SN, et al. International Hepato-Pancreato-Biliary Association (HPB) 2013; 15(4): 286-293.
A randomized trial of emtricitabine/tenofovir disoproxil fumarate after hepatitis B immunoglobulin withdrawal post-liver transplant.
Teperman LW, Poordad F, et al. Liver Transplantation 2013; 19(6):594-601
Heart transplantation
Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial.
Eisen HJ, Kobashigawa J, et al. American Journal of Transplantation 2013; 13(5):1203-16
Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine A in combination with mycophenolate mofetil after heart transplantation.
Guethoff S, Meiser BM, et al. Transplantation 2013; 95(4): 629-634.
Lung transplantation
CNE Article: Pain after lung transplant: high-frequency chest wall oscillation vs chest physiotherapy.
Esguerra-Gonzalez A, Ilagan-Honorio M, et al. American Journal of Critical Care 2013; 22(2): 115-124.