To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
August 2013
Kidney transplantation
A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients.
Flechner SM, Gurkan A, et al. Transplantation 2013; 95(10): 1233-1241.
Mizoribine versus mycophenolate mofetil in combination therapy with tacrolimus for de novo kidney transplantation: evaluation of efficacy and safety.
Ju MK, Huh KH, et al. Transplantation Proceedings 2013; 45(4): 1481-1486.
Cost-effectiveness of hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: A randomized study.
Klop K W, Kok NF, et al. Transplantation 2013; 96(2):170-5.
Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid Intima media thickness in renal transplant recipients.
Mourer JS, de Koning EJ, et al. Transplantation 2013; 96(1):49-57
The risk of polyomavirus-associated graft nephropathy is increased by a combined suppression of CD8 and CD4 cell-dependent immune effects.
Renner FC, Dietrich H, et al. Transplantation Proceedings 2013;45(4): 1608-1610.
Alefacept combined with tacrolimus, mycophenolate mofetil and steroids in de novo kidney transplantation: A randomized controlled trial.
Rostaing L, Charpentier B, et al. American Journal of Transplantation 2013; 13(7):1724-33
Liver transplantation
Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study.
Saliba F, De Simone P, et al. American Journal of Transplantation 2013; 13(7):1734-45
Randomized multicenter trial comparing tacrolimus plus mycophenolate mofetil with tacrolimus plus steroids among HCV-positive recipients of living donor liver transplantation.
Takada Y, Kaido T, et al. Liver Transplantation 2013; 19(8):896-906
Lung transplantation
Interobserver variability in grading transbronchial lung biopsy specimens after lung transplantation.
Bhorade SM, Husain AN, et al. Chest 2013; 143(6): 1717-1724.