To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
April 2014
Kidney transplantation
Prospective randomized controlled trial of rabbit antithymocyte globulin compared with IL-2 receptor antagonist induction therapy in kidney transplantation.
Pilch NA, Taber DJ, Moussa O, et al. Annals of Surgery 2014; 259 (5): 888-893.
15-year follow-up of a multicenter, randomized, calcineurin inhibitor withdrawal study in kidney transplantation.
Roodnat JI, Hilbrands LB, Hene RJ, et al. Transplantation 2014; 98(1): 47-53
Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients.
Silva HT, Yang HC, Meier-Kriesche HU, et al. Transplantation 2014; 97(6): 636-641
Liver transplantation
De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial.
Asrani SK, Wiesner RH, Trotter JF, et al. American Journal of Transplantation. 2014; 14, 356-66.
A randomized clinical trial testing the anti-inflammatory effects of pre-emptive inhaled nitric oxide in human liver transplantation
Lang JD, Smith AB, Brandon A, et al. PLoS ONE. 2014; 9: e86053.
Everolimus and early calcineurin inhibitor withdrawal: 3-year results from a randomized trial in liver transplantation.
Sterneck M, Kaiser GM, Heyne N, et al. American Journal of Transplantation. 2014; 14: 701-710.
Heart transplantation
Randomized and comparative study between two intra-hospital exercise programs for heart transplant patients.
Kawauchi TS, Almeida PO, et al. Revista Brasileira de Cirurgia Cardiovascular. 2013; 28, 338-46.
Interval training does not modulate diastolic function in heart transplant recipients.
Monk-Hansen T, Dall CH, et al. Scandinavian Cardiovascular Journal 2014; 48(2): 91-98
Lung transplantation
Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection
Greenland JR, Jewell NP, et al. American Journal of Transplantation 2014; 14(4): 831-840
Cold ischemia or topical-ECMO for lung preservation: a randomized experimental study.
Mariani AW, Medeiros IL, Pego-Fernandes PM, et al. Sao Paulo Medical Journal. 2014; 132; 28-35.