To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
April 2015
Kidney transplantation
Homoarginine and Clinical Outcomes in Renal Transplant Recipients Results From the Assessment of Lescol in Renal Transplantation Study.
Drechsler C, Pihlstrøm H, et al. Transplantation 2015 Jul;99(7):1470-6
Anti-B cell therapy with rituximab as induction therapy in renal transplantation.
Joosten I, Baas MC, Kamburova EG, et al. Transplant Immunology 2014; 31(4):207-9.
Isoniazid treatment to prevent TB in kidney and pancreas transplant recipients based on an interferon-g-releasing assay: an exploratory randomized controlled trial.
Kim S-H, Lee S-O. Journal of Antimicrobial Chemotherapy. 2015 May; 70(5): 1567-72
A Randomized Trial of Everolimus and Low-dose Cyclosporine in Renal Transplantation: With or Without Steroids?
Ponticelli C, Carmellinib M, Tisonec G, et al. Transplantation Proceedings 2014; 46:3375-3382.
A Novel and Personalized Rehabilitation Program for Obese Kidney Transplant Recipients.
Tzvetanov I, West-Thielke P, D’Amico G, et al. Transplantation Proceedings 2014; 46:3431-3437.
Rituximab as Induction Therapy After Renal Transplantation: A Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Safety.
van den Hoogen MWF, Kamburova EG, et al. American Journal of Transplantation 2015; 15(2): 407-416.
Liver transplantation
Hepatitis B virus quasispecies evolution after liver transplantation in patients under long-term lamivudine prophylaxis with or without hepatitis B immune globulin.
Buti M, Tabernero D, et al. Transplant Infectious Disease. 2015 Apr; 17(2): 208-20
Cytokine Release After Treatment With Rituximab in Renal Transplant Recipients.
Kamburova E, van den Hoogen MWF, et al. Transplantation 2015 Sep;99(9):1907-11
Protein Kinase C Inhibitor Sotrastaurin in De Novo Liver Transplant Recipients: A Randomized Phase II Trial.
Pascher A, Simone De P, et al. American Journal of Transplantation. 2015 May; 15(5): 1283-92
Various organs
The Effect of Psychological Support for the Relatives of Intensive Care Unit Patients on Cadaveric Organ Donation Rate.
Adanir T, Erdogan I, et al. Transplantation Proceedings 2014; 46(10): 3249-3252.