To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
July 2015
Kidney transplantation
Subclinical Lesions and Donor-Specific Antibodies in Kidney Transplant Recipients Receiving Tacrolimus-Based Immunosuppressive Regimen Followed by Early Conversion to Sirolimus
de Sandes-Freitas TV, Felipe CR, et al Transplantation 2015 [Record in progress]
Urinary biomarkers after donor nephrectomy
Hoogendijk-van den Akker JM, Warle MC, et al. Transplant International 2015 May;28(5):544-52
New-Onset Diabetes After Transplantation: Results From a Double-Blind Early Corticosteroid Withdrawal Trial
Pirsch JD, Henning AK, et al. American Journal of Transplantation 2015 Jul;15(7):1982-90
Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients—A Prospective, Randomized Study
Storset E, Ã…sberg A, et al Transplantation 2015 [Record in progress]
A Single Center, Open-label, Randomized Pilot Study to Evaluate the Safety and Efficacy of Tacrolimus Modified Release, ADVAGRAF, Versus Tacrolimus Twice Daily, PROGRAF, in Stable Renal Recipients (SINGLE).
Yang SS, Choib JY, et al Transplantation Proceedings 2015; 47(3): 617-621
Liver transplantation
Adaptive Support Ventilation Versus Synchronized Intermittent Mandatory Ventilation With Pressure Support in Weaning Patients After Orthotopic Liver Transplantation
Celli P, Privatoa E, et al Transplantation Proceedings 2014; 46: 2272-2278.
Impact of tacrolimus and mycophenolate mofetil regimen versus a conventional therapy with steroids on cardiovascular risk in liver transplant patients
Cuervas-Mons V, Herrero JI, et al Clinical Transplantation 2015 Aug;29(8):667-77.
Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients – a prospective, randomized, double-blind, phase III trial
Hoffmann K, Ganten T, et al BMC Cancer 2015; 15(1): 392.
Heart transplantation
RAndomized Comparison of raDIal vs. femorAL Access for Routine Catheterization of Heart Transplant Patients (RADIAL-Heart Transplant Study)
Scalone G, Brugaletta S, et al Transplantation Proceedings 2014; 46(10): 3262-3267.
Various organs
Effect of Web-Based Training for Department of Motor Vehicle Staff on Donor Designation Rates: Results of a Statewide Randomized Trial
Degenholtz HB, Resnick A, et al American Journal of Transplantation 2015; 15(5): 1376-1383.