To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
February 2016
Kidney transplantation
Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial).
Coombes JS, Sharman JE, et al. Am J Clin Nutr 2016; Jan;103(1):283-9.
A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism.
Cruzado JM, Moreno P, et al. J Am Soc Nephrol 2015 [record in progress]
A Prospective Randomized Trial on the Effect of Using an Electronic Monitoring Drug Dispensing Device to Improve Adherence and Compliance.
Henriksson J, Tyden G, et al. Transplantation 2016 Jan;100(1):203-9
Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Santos AHJ, Casey MJ, et al. J Clin Hypertens 2015 [record in progress].
A Double-blind, Double-dummy, Flexible-design Randomized Multicenter Trial: Early Safety of Single- vs. Divided-dose Rabbit Anti-thymocyte Globulin Induction in Renal Transplantation.
Stevens RB, Wrenshall LE, et al. American Journal of Transplantation 2015 [record in progress].
Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients: A Randomized, Controlled, Phase IIB Trial.
Thomas RAB, Czopek A, et al. Transplantation 2016; 100(1): 176-183.
Liver transplantation
Sofosbuvir and ribavirin for treatment of compensated recurrent hepatitis C virus infection after liver transplantation.
Charlton M, Gane E, et al. Gastroenterology 2015; 148(1): 108-117.
Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial.
Geissler EK, Schnitzbauer AA, et al. Transplantation 2016 Jan;100(1):116-25
Early Enteral Feeding After Living Donor Liver Transplantation Prevents Infectious Complications: A Prospective Pilot Study.
Kim JM, Joh J, et al. Medicine 2015; 94(44): e1771.
Trabecular bone score in patients with liver transplants after one year of risedronate treatment.
Librizzi S, Guadalix S, et al. Transplant International 2015 [record in progress].