To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
June 2016
Kidney transplantation
Efficacy of Psychoeducational Intervention on Allograft Function in Kidney Transplant Patients: 10-Year Results of a Prospective Randomized Study.
Breu-Dejean N, Driot D, et al. Experimental & Clinical Transplantation 2016; 14(1): 38-44.
The Consistency and Reporting of Quality-of-Life Outcomes in Trials of Immunosuppressive Agents in Kidney Transplantation: A Systematic Review and Meta-analysis.
Howell M, Wong G, et al. American Journal of Kidney Diseases 2016; 67(5): 762-774.
Long-term clinical impact of adaptation of initial tacrolimus dosing to CYP3A5 genotype.
Pallet N, Etienne I, et al. American Journal of Transplantation 2016;16(9):2670-5.
Comparison of survival outcomes between Expanded Criteria Donor and Standard Criteria Donor kidney transplant recipients: a systematic review and meta-analysis.
Querard A, Foucher Y, et al. Transplant International 2016; 29(4): 403-415.
Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial.
Rostaing L, Bunnapradist S, et al American Journal of Kidney Diseases 2016; 67(4): 648-659.
A prospective study of renal transplant recipients reveals an absence of primary JC polyomavirus infections.
Saundh BK, Baker R, et al. Journal of Clinical Virology 2016; 77: 101-105.
Liver transplantation
Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform.
Zarrinpar A, Lee DH, et al. Science Translational Medicine 2016; 8(333): 333ra349.
Heart transplantation
Development of a Transplantation Risk Index in Patients With Mechanical Circulatory Support: A Decision Support Tool.
Johnston LE, Grimm JC, et al. JACC Heart Failure 2016; 4(4): 277-286.
Wound complications and surgical events in de novo heart transplant patients treated with everolimus: Post-hoc analysis of the SCHEDULE trial.
Rashidi M, Esmaily S, et al. International Journal of Cardiology 2016; 210: 80-84.
Various organs
Organ donation video messaging in motor vehicle offices: results of a randomized trial.
Rodrigue JR, Fleishman A, et al. Progress in Transplantation 2015; 25(4): 332-338.