To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
August 2016
Kidney transplantation
Does pre-emptive transplantation versus post start of dialysis transplantation with a kidney from a living donor improve outcomes after transplantation? A systematic literature review and position statement by the Descartes Working Group and ERBP.
Abramowicz D, Hazzan M, et al. Nephrology Dialysis Transplantation 2016; 31(5): 691-697.
A randomized, prospective comparison of transition to sirolimus-based CNI-minimization or withdrawal in African American kidney transplant recipients.
Fleming JN, Taber DJ, et al. Clinical Transplantation 2016; 30(5): 528-533.
Efficacy and Safety of Low-Dose Versus Standard-Dose Valganciclovir for Prevention of Cytomegalovirus Disease in Intermediate-Risk Kidney Transplant Recipients.
Halim MA, Al-Otaibi T, et al. Experimental & Clinical Transplantation 2016 [record in progress].
Ultrasound-guided subcostal transversus abdominis plane blocks with liposomal bupivacaine vs. non-liposomal bupivacaine for postoperative pain control after laparoscopic hand-assisted donor nephrectomy: a prospective randomised observer-blinded study.
Hutchins JL, Kesha R, et al. Anaesthesia 2016;71(8):930-7
Optimal management of distal ureteric strictures following renal transplantation: a systematic review.
Kwong J, Schiefer D, et al. Transplant International 2016; 29(5): 579-588.
Early home-based group education to support informed decision-making among patients with end-stage renal disease: a multi-centre randomized controlled trial.
Massey EK, Gregoor PJHS, et al. Nephrology Dialysis Transplantation 2016; 31(5): 823-830.
Plasma-Derived C1 Esterase Inhibitor for Acute Antibody Mediated Rejection Following Kidney Transplantation: Results of a Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Montgomery RA, Orandi BJ, et al. American Journal of Transplantation 2016 [record in progress].
A four-drug combination therapy consisting of low-dose tacrolimus, low-dose mycophenolate mofetil, corticosteroids, and mizoribine in living donor renal transplantation: A randomized study.
Yan T, Wu X, et al. SAGE Open Medicine 2016; 4: 2050312116643672.
Liver transplantation
Perioperative Prostaglandin E1 Infusion In Live Donor Liver Transplantation: A Double Blind Placebo Controlled Randomized Trial.
Bharathan VK, Chandran B, et al. Liver Transplantation 2016;22(8):1067-74
Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.
Manns M, Samuel D, et al. The Lancet Infectious Diseases 2016; 16(6): 685-697.