To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
November 2016
Kidney transplantation
Aspirin Use and Incident Cardiovascular Disease, Kidney Failure, and Death in Stable Kidney Transplant Recipients: A Post Hoc Analysis of the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial.
Dad T, Tighiouart H, et al. American Journal of Kidney Diseases 2016; 68(2): 277-286.
Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.
Dedeoglu B, Meijers RWJ, et al. PLoS ONE 2016 [Electronic Resource] 11(3): e0150826.
5-year follow-up of a randomized clinical study comparing everolimus plus reduced-dose cyclosporine with mycophenolate mofetil plus standard-dose cyclosporine in de novo kidney transplantation: Retrospective single center assessment.
Hiramitsu T, Okada M, et al. International Immunopharmacology 2016; 39: 192-198.
Fish oil for kidney transplant recipients.
Lim AKH, Manley KJ, et al. Cochrane Database of Systematic Reviews 2016; 8: CD005282.
Preconditioning Therapy in ABO-Incompatible Living Kidney Transplantation: A Systematic Review and Meta-Analysis.
Lo P, Sharma A, et al. Transplantation 2016; 100(4): 933-942.
MAGIC Study: Aims, Design and Methods using SystemCHANGETM to Improve Immunosuppressive Medication Adherence in Adult Kidney Transplant Recipients.
Russell CL, Moore S, et al. BMC Nephrology 2016; 17(1): 84.
Liver transplantation
Cost-effectiveness of everolimus plus reduced tacrolimus in de novo liver-recipients in the Italian setting.
Bianic F, Campbell R, et al. Journal of Medical Economics 2016; 19(9):866-73
Effect of Covered Metallic Stents Compared With Plastic Stents on Benign Biliary Stricture Resolution: A Randomized Clinical Trial.
Cote GA, Slivka A, et al. JAMA 2016; 315(12): 1250-1257.
Corticosteroid-Sparing and Optimization of Mycophenolic Acid Exposure in Liver Transplant Recipients Receiving Mycophenolate Mofetil and Tacrolimus: A Randomized, Multicenter Study.
Saliba F, Rostaing L, et al. Transplantation 2016; 100(8): 1705-1713.
Heart transplantation
Outcomes and risk factors for listing for heart transplantation after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial.
Kulkarni A, Neugebauer R, et al. Journal of Heart & Lung Transplantation 2016; 35(3): 306-311.