To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
February 2014
Kidney transplantation
A randomized, controlled trial of everolimus based dual immunosuppression vs standard of care in de novo kidney transplant recipients.
Chadban S, Eris J, et al. Transplant International 2014; 27(3): 302-11.
Randomized Controlled Pilot Study of B Cell-Targeted Induction Therapy in HLA Sensitized Kidney Transplant Recipients.
Ejaz NS, Shields AR, et al. American Journal of Transplantation 2013; 13(12): 3142-3154.
Efficacy and safety of vildagliptin in new-onset diabetes after kidney transplantation-a randomized, double-blind, placebo-controlled trial.
Haidinger M, Werzowa J, et al. American Journal of Transplantation 2014;14(1):115-23
One-year multicenter double-blind randomized clinical trial on the efficacy and safety of generic cyclosporine (Iminoral) in de novo kidney transplant recipients.
Khatami SM, Taheri S, et al. Experimental & Clinical Transplantation [record in progress].
The efficacy and safety of cyclosporine reduction in de novo renal allograft patients receiving sirolimus and corticosteroids: results from an open-label comparative study.
Muhlbacher F, Neumayer HH, et al. Transplant International 2014;27(2):176-86
Planned randomized conversion from tacrolimus to sirolimus-based immunosuppressive regimen in de novo kidney transplant recipients.
Silva HT, Felipe CR, et al. American Journal of Transplantation 2013; 13(12): 3155-3163.
Liver transplantation
The effect of octreotide on urine output during orthotopic liver transplantation and early postoperative renal function; a randomized, double-blind, placebo-controlled trial.
Sahmeddini M A, Amini A, et al. Hepatitis Monthly 2013; 13(9): e12787.
Heart transplantation
Cardiac signalling molecules and plasma biomarkers after cardiac transplantation: Impact of tacrolimus versus cyclosporine.
White M, Cantin B, et al. Journal of Heart & Lung Transplantation 2013; 32(12): 1222-1232
Other
Protocol of a cluster randomized trial of an educational intervention to increase knowledge of living donor kidney transplant among potential transplant candidates.
Weng FL, Brown DR, et al. BMC Nephrology 2013; 14(1): 256.