To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
December 2011
Kidney transplantation
The Influence of Cytomegalovirus Infections on Patient and Renal Graft Outcome: A 3-year, Multicenter, Observational Study (Post-ECTAZ Study).
Abou-Ayache R, Buchler M, et al. Transplantation Proceedings. 43(7): 2630-5, 2011.
Randomized Trial of Dual Antibody Induction Therapy with Steroid Avoidance in Renal Transplantation.
Ciancio G, Gaynor JJ, et al. Transplantation, 92(12): 1348-1357, 2011.
High-dose Erythropoietin Has No Effect on Short- or Long-term Graft Function following Deceased Donor Kidney Transplantation.
Hafer C, Becker T, et al. Kidney International, 81(3): 314-320, 2011.
Effects of Diltiazem on Pharmacokinetics of Tacrolimus in relation to CYP3A5 Genotype Status in Renal Recipients: from Retrospective to Prospective.
Li JL, Wang XD, et al. The Pharmacogenomics Journal. 11(4): 300-306, 2011.
Alemtuzumab Induction Therapy in Highly Sensitized Kidney Transplant Recipients.
Lu T M, Yang S L, et al. Chinese Medical Journal. 124(5): 664-668, 2011.
Three-Year Outcomes from BENEFIT, a Randomized, Active-Controlled, Parallel-Group Study in Adult Kidney Transplant Recipients.
Vincenti F, Larsen CP, et al. American Journal of Transplantation, 12(1):217-210, 2012.
Liver transplantation
Sequential versus Contemporaneous Portal and Arterial Reperfusion during Liver Transplantation.
Adani GL, Rossetto A, et al. Transplantation Proceedings. 43(4): 1107-110, 2011.
Oxygen Persufflation as Adjunct in Liver Preservation (OPAL): Study Protocol for a Randomized Controlled Trial.
Minor T, Putter C, et al. Trials. 12(1): 234, 2011.
Mycophenolate Mofetil Monotherapy in Liver Transplantation: 5-year Follow-up of a Prospective Randomized Trial.
Schmeding M, Kiessling A, et al. Transplantation. 92(8): 923-929, 2011.
Other
Calcineurin Inhibitors Acutely Improve Insulin Sensitivity without Affecting Insulin Secretion in Healthy Human Volunteers.
Ozbay LA, Moller N, et al. British Journal of Clinical Pharmacology, 73(4); 536-545, 2012